However, even the latter has both a high diagnostic false positive and false negative rate, and ultimately the tumor is often resected, often unnecessarily, while, on the other hand, the delays due to the diagnostic work might also compromise optimal care for those tumors that proof malignant. The sizeable group of patients with larger or denser tumors end up with an arduous workup that frequently includes additional imaging studies, hormonal testing, and biopsy. Unfortunately, CT imaging alone is very limited in its ability to distinguish benign from malignant adrenal tumors only very small and hypodense lesions can be easily dismissed as benign.
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